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  The FDA target action date (PDUFA date) is set for November 28, 2025 If approved, sibeprenlimab would offer patients a convenient single-dose prefilled syringe for subcutaneous injection every four weeks intended for at home self-administration Sibeprenlimab has Breakthrough Therapy designation based on favorable results from the Phase 2 (ENVISION) trial (NCT04287985) 26 May 2025 Monday -  Otsuka Pharmaceutical, Co. Ltd. (Otsuka) and Otsuka Pharmaceutical Development & Commercialization, Inc. (OPDC) announce the U.S. Food and Drug Administration (FDA) has accepted for review the Biologics License Application (BLA) for sibeprenlimab, an investigational monoclonal antibody that selectively inhibits the activity of APRIL ( A PR oliferation- I nducing L igand) in adults with immunoglobulin A nephropathy (IgAN). APRIL plays a key role in the pathogenesis of IgAN as explained by the 4-hit process, in which pathogenic galactose-deficient IgA (Gd-IgA1) is produced, lead...

      

      

    

    

     

Nikkei 225 Volatility Index - Fri 30 May 2025 23.74 (+1.50% +0.35)      

Nikkei 225 Summary Nikkei declines as US-China trade deal stalls; Wall Street slips as Trump says China violated preliminary trade agreement - Fri 30 May 2025 Chipmakers lead losers after US Treasury Secretary Bessent says US-China trade negotiation has hit a little bit of a road block with inputs required by Presidents from both countries. Bucking the trend, pharmaceutical firm Otsuka jumps +6.82% on news of its new kidney drug Sibeprenlimab obtaining US FDA acceptance and priority review this week. Meanwhile, Wall Street slips as Trump says that China has violated preliminary trade agreements. Nikkei225  37,965.10 (-467.88 -1.22%) 95 up 127 down 3 flat JGB 10YR   1.503% (-0.016)             USD/JPY    143.83 (-0.36 -0.2497%)    

Topix - Fri 30 May 2025 Topix   2,801.57 (-10.45 -0.37%)    

JREIT Index - Fri 30 May 2025 JREIT   1,736.74 (-3.35 -0.19%)        

     

      

       

     

     

   

Nikkei 225 Volatility Index - Thu 29 May 2025 23.39 (+0.82% +0.19)    

Nikkei 225 Summary Chipmakers lead Nikkei's 710 point surge; Wall Street positive on Nvidia earnings beat - Thu 29 May 2025 Nikkei surges 710.58 points in a broad-based rally led by chipmakers as Trump tariffs are temporarily halted by a US trade court. Meanwhile, Wall Street edges up on optimism for the AI trade to continue after Nvidia's Q1 earnings beat.  Nikkei225  38,432.98 (+710.58 +1.88%) 179 up 38 down 8 flat JGB 10YR   1.524% (+0.011)             USD/JPY    144.05 (-0.77 -0.5317%)    

Topix - Thu 29 May 2025 Topix   2,812.02 (+42.51 +1.53%)    

JREIT Index - Thu 29 May 2025 JREIT   1,740.09 (-8.46 -0.48%)    

  

'The Sea God Sees' was Rocket Lab's third mission for Institute for Q-shu Pioneers of Space, Inc. (iQPS), an Earth-imaging company from Japan. 'The Sea God Sees’ launched from Rocket Lab Launch Complex 1 in New Zealand on May 17, 2025. The mission deployed a single synthetic aperture radar (SAR) imaging satellite called QPS-SAR-10 (nicknamed “WADATSUMI-I” for the Japanese god of the sea) to a 575km circular Earth orbit, from where the satellite will join the rest of the iQPS constellation in providing high resolution images and Earth monitoring services globally. The mission was the third overall Electron launch for iQPS and the second in a line-up of eight dedicated missions across 2025 and 2026 to deploy iQPS’s constellation.    About iQPS  Institute for Q-shu Pioneers of Space, Inc. (iQPS), is a pioneering space startup founded in 2005 by two Emeritus Professors from Kyushu University and a rocket developer with the mission of establishing a space indust...

   

 

 

 

 

Nikkei 225 Volatility Index - Wed 28 May 2025 23.20 (-3.93% -0.95)  

Nikkei 225 Summary Space startup iQPS surges 21%; defense stocks & banks lose steam; Wall Street pauses for Nvidia earnings - Wed 28 May 2025 Defense stocks & banks pull back slightly as the rally from 37,000 takes a pause despite strong gains on Wall Street overnight. The star performer today, space startup iQPS (2,249 yen +400 +21.63%) surged +21.63% as investors take notice of its recent successful satellite launch of the "Sea God - Wadatsumi-I" from New Zealand. Institute for Q-shu Pioneers of Space, Inc. (iQPS 5595), is a pioneering space startup founded in 2005 by two Emeritus Professors from Kyushu University and a rocket developer with the mission of establishing a space industry in Japan’s Kyushu region.  Meanwhile, Wall Street pauses cautiously, hoping all the best for Nvidia's earnings call after market closes today.  Nikkei225  37,722.40 (-1.71 -0.00%) 121 up 102 down 2 flat JGB 10YR   1.519% (+0.056)           ...

Topix - Wed 28 May 2025 Topix   2,769.51 (+0.02 0.00%)

JREIT Index - Wed 28 May 2025 JREIT   1,748.55 (+11.49 +0.66%)    

  

   

   

   

     

   

Nikkei 225 Volatility Index - Tue 27 May 2025 24.15 (-1.07% -0.26)  

Nikkei 225 Summary Nikkei extend gains as BOJ unlikely to hike rates soon; US Consumer Confidence rebounds in May - Tue 27 May 2025 Nikkei extend gains with the tech & banking sectors leading as investors return to Japanese equities believing that this recovery has more legs to run, supported by BOJ's dovish hints. BOJ governor Kazuo Ueda hinted at an international conference for central bankers in Tokyo that the BOJ is unlikely to hike rates so soon amid high levels of uncertainty over trade policies and Japan-US negotiation outcomes. Meanwhile, Wall Street jumps as US consumer confidence rebounds in May, breaking 5 months of decline. Nikkei225  37,724.11 (+192.58 +0.51%) 156 up 65 down 4 flat JGB 10YR   1.495% (-0.015)             USD/JPY    144.33 (+1.49 +1.04%)

Topix - Tue 27 May 2025 Topix   2,769.49 (+17.58 +0.64%)  

JREIT Index - Tue 27 May 2025 JREIT   1,737.06 (+9.04 +0.52%)